The results showed that CXCL8 expression in colon cancer tissues was significantly positively correlated with stromal score (r = 0.416, p < 0.0001), ESTIMATE immune score (r = 0.465, p < 0.001) (Figure 3A,B), tumor mutation burden (TMB) (p = 0.00057) (Figure 3C) and microsatellite instability (MSI) (p = 1.4 × 10−5) (Figure 3D), and negative correlation with mismatch repair protein EpCAM mutation (p < 0.05) (Figure 3E). The gene discussed is EPCAM; the disease is neoplasm.