The results could provide a theoretical basis for clarifying the mechanism of anti-PD-1/PD-L1 or anti-CTLA4 primary drug resistance in colon cancer, and provide a new idea for solving the phenomenon of anti-PD-1/PD-L1 or anti-CTLA4 primary drug resistance in colon cancer. The gene discussed is CTLA4; the disease is malignant colon neoplasm.