TNF and obesity due to melanocortin 4 receptor deficiency: Patients with a sarcopenic obesity profile have a proinflammatory milieu (high levels of leptin, chemerin, and resistin, tumor necrosis factor (TNF)-α, interleukin (IL)-6, interferon (INF)-γ), and a decreased concentration of adiponectin and IL-15, which contributes to the progression of HCC [12].