On the contrary, a higher release of IFNγ and IL-2 was observed in the supernatants of the tumor cells co-cultured with Pan T when treated with atezolizumab plus ipilimumab, reaching a concentration of IFNγ of about 3000 pg/mL and 2600 pg/mL, respectively, in the co-cultures of MDA-MB-231 and BT-549 cell lines (about 2-fold higher, with respect to the combination of the novel mAbs) (Figure 6B and Figure 7B). Here, IL2 is linked to neoplasm.