MKI67 and neoplasm: In order to further investigate whether pre-treatment systemic lymphocyte ratios represented reliable and informative prognostic biomarkers other than known clinical–pathologic features, a multivariate Cox analysis was performed taking into account blood-derived inflammatory markers together with patient age, cT, cN, Ki67 levels at core biopsy, tumor grade and histotype, tumor biological portrait, and NACT regimen.