TFPI2 and gastric cancer: As shown in Figure 3A, the sensitivities of ELMO1, ZNF582 and TFPI2 alone for detecting GC were 33.9%, 56.0% and 27.5%, respectively; the combined used of ELMO1 and ZNF582 improved the sensitivity to 67.0% and the combination of three methylation markers could further improve the sensitivity to 67.9%.