Consistent with studies on the overexpression of this TF relating to a worse outcome and increased steroid metabolism [23,24,67], the NR5A1 regulon correlated with low OS in the multivariate Cox and Kaplan-Meier analyses in the TCGA-ACC cohort, which was also confirmed in the ENSAT cohort (Figure 6). Here, NR5A1 is linked to adrenal cortex carcinoma.