For example, Kim et al. (2012) [76] showed that Methyl 2-cyano-3,11-dioxo-18β-olean-1,12-dien-30-oate (CDODA-Me) could increase ZBTB4 expression in vivo and in vitro, having an antitumorigenic activity in prostate cancer. Here, ZBTB4 is linked to Familial prostate cancer.