Regarding HCC risk, development of HCC showed inverse associations compared to persons with cirrhosis with two proteins, including DEFA-1 [ORC2v.C1 = 0.06 (95% CI: 0.02–0.20)] and ITGAM [ORC2v.C1 = 0.20 (95% CI: 0.08–0.40)]. The gene discussed is DEFA1; the disease is hepatocellular carcinoma.