CDA indicated 12 markers implicated in the progression of cirrhosis vs. controls, including DEFA-1, artemin (ARTN), regenerating family member 1 alpha (REG1A), three c-c motif chemokines (CCL3,CCL4, CCL18), cluster of differentiation 40 (CD40), C-X-C motif chemokine ligand 10 (CXCL10), extracellular newly identified RAGE-binding protein (EN-RAGE), latency-associated peptide transforming growth factor beta-1 (LAP/TGF-beta-1), human monocyte chemoattractant protein (MCP4), and programmed death-ligand 1 (PD-L1). This evidence concerns the gene CD40 and Cirrhosis.