In a sensitivity analysis aimed at assessing temporality on the observed associations, we found the magnitude of the associations of DEFA-1, ITGAM and SCF with cirrhosis development to be notably stronger among those who developed cirrhosis early (<10.75 years after sample collection) compared to those who developed cirrhosis late (≥10.75 years after sample collection) (Figure 1). The gene discussed is DEFA1; the disease is Cirrhosis.