ACVR1B and neoplasm: They also found that miR574-5p and miR574-3p target endogenous QKI6 and ACVR1B, respectively, where miR574-5p acts as a tumor promoter and miR574-3p acts as a tumor suppressor, suggesting that 5p-arm and 3p-arm of miRNA could play a different role in tumor progression.