miR124-3p affects the CREBRF-ATG5/CREB3 axis, while miR766-3p affects the NR3C2-c-Myc/β-catenin axis; therefore, the combined targeting of these two miRNAs complement each other and shows an additive effect on sensitizing cancer cells to chemo-radiotherapy. This evidence concerns the gene NR3C2 and cancer.