CREB3 induces GBM cell proliferation and invasion by inhibiting apoptosis via downregulating proapoptotic proteins—Bax, active caspase 3, p-PERK, p-eIF2α, and ATF4, suggesting that CREB3 might inhibit anti-cancer drug-induced apoptosis [44]. This evidence concerns the gene EIF2AK3 and glioblastoma.