Only one receptor termed TNF-Receptor-1 (TNFR-1) (p55) was shown to be important for the protection against bacterial infection and the proinflammatory activity of endotoxins [37,38,39], while the role of the second TNFR-2 p75 remains to some extent unresolved to this day, despite a demonstrated function in cell proliferation [40], regulatory T cell proliferation [2], and general support for p55 [41,42]. This evidence concerns the gene TNFRSF1A and bacterial infectious disease.