Of note, TERT expression and telomerase activity in cervical samples of women diagnosed with ASCUS (abnormal squamous cells of undetermined significance), LSIL (low-grade squamous intraepithelial lesion), HSIL (high-grade squamous intraepithelial lesion) and invasive cervical carcinoma have been shown to increase with disease severity [60,91,92]. The gene discussed is TERT; the disease is squamous cell intraepithelial neoplasia.