However, in cancer cells the stringent control of TERT transcription is disrupted by the aberrant expression of TERT promoter activators, primarily MYC, the first oncoprotein demonstrated to induce the telomerase expression, and by nuclear factor kappa B (NF-κB) signaling that is considered the master regulator of TERT activation in cancer cells [19,20,21]. This evidence concerns the gene TERT and cancer.