TERT and neoplasm: Moreover, the study of the gene expression profiles of more than 9000 tumors, including virus-related cancers, showed that TERT mRNA levels were associated with immune suppressive signatures via TERT-dependent activation of endogenous retroviruses, which by forming double-stranded RNAs induced the RIG-1/MDA5-MAVS signaling pathway, interferon signaling, chemokines’ expression and recruitment of suppressive T cells in the tumor [166].