By investigating CML CD34+ cells treated with TKI and untreated, as well as CML LSC and normal haemopoietic stem cells (HSC), we identified a list of 227 genes that are TKI-independent (TKI-independent) and potentially BCR-ABL1 TK-independent. The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.