Therefore, for cN0 NSCLC patients with a high hazard of lymph nodal metastasis—such as the increased level of carcinoembryonic antigen, the high standardized uptake value of PET/CT, and the enlarged tumor size—RATL may be a favorable surgical approach over VATL in the context of leading to more complete staging. This evidence concerns the gene CEACAM5 and non-small cell lung carcinoma.