SOCS3 and central nervous system cancer: This protein is highly expressed in gliomas, predominantly in high-grade gliomas, and is associated with increased cellular proliferation and invasion in human glioma cell lines and mouse models, possibly through the inhibition of the regulators of the JAK2/STAT3 signaling pathway, the suppressor of cytokine signaling 3 (SOCS-3), and Src homology 2 [SH2]-containing phosphatase-1 (SHP-1), eventually leading to the activation of the JAK2/STAT3 signaling pathway [47].