In addition, the proposed NPs showed multimodal anticancer activities against U87MG, and P3#GBM brain cancer cells via (i) activating reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, leading to increasing hydrogen peroxide levels, (ii) increasing the intracellular iron levels which will eventually react with the hydrogen peroxide (Fenton reaction) forming reactive oxygen species (ROS) which induce ferroptosis, (iii) apoptosis caused by Cs, and (iv) si-GPX4 downregulating the expression of GPX4 and synergistically improving the anticancer effect. This evidence concerns the gene GPX4 and glioblastoma.