Another recent study reported the formulation of siRNA-loaded lipopolyplexes formed of phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and polyethyleneimine (PEI) to the target signal transducer and activator of transcription 3 (STAT3), an essential signaling protein responsible for the development of glioblastoma. Here, STAT3 is linked to glioblastoma.