A recent study reported the design of β-cyclodextrin (β-CD)-coated PAMAM-entrapped gold NPs to deliver two types of siRNAs; B-cell lymphoma/leukemia-2 (Bcl-2) siRNA and vascular endothelial growth factor (VEGF) siRNA to glioblastoma cells effectively [165]. The gene discussed is VEGFA; the disease is glioblastoma.