What is more, ZFP91 can not only activate HIF-1α through NF-κB/p65 [44] but also positively regulate the production of inflammatory cytokine IL-1β in macrophages by activating the MAPKs and atypical caspase-8 inflammasome [45,48], which advances the proliferation and tumorigenesis of colon cancer. The gene discussed is NFKB1; the disease is malignant colon neoplasm.