PTGS2 and colonic neoplasm: Furthermore, downregulated ZFP36 can advance the development of colon cancer (CT26 cell line) in mice via elevating the expression of inflammatory factors IL-23, HuR [27,28], vascular endothelial growth factor (VEGF), cyclooxygenase 2 (COX-2) [29], ZEB1, Sox9, and MACC1 [30] or increasing the stability of vitamin D receptor (VDR) [31] and claudin-1 [32].