MZF1 and colorectal carcinoma: Furthermore, a recent study confirmed that downregulated GSK3β in CRC cells can promote the expression of FTO by mediating FTO ubiquitination, FTO promotes the expression of the MZF1 protein by removing the m6A mRNA modification of MZF1, and the MZF1 protein activates the MZF1/C-MYC axis to advance cell proliferation and inhibit cell apoptosis [104].