Previous studies have illustrated that ZNF70, as a target between macrophages and colon cancer cells, promotes the secretion of IL-1β by macrophages by regulating the activation of NLRP3 inflammasome and STAT3 in macrophages (THP-1) and then boosts the proliferation of colorectal cancer cells (HCT116 cell line) [64]. Here, IL1B is linked to colonic neoplasm.