Mudduluru et al. [74] first demonstrated that MZF1 overexpression in colorectal (RKO and SW480 cell lines) cancer cells can induce tumor cell proliferation, migration, and invasion by binding to the receptor tyrosine kinase (Axl) promoter gene, transactivating promoter activity and enhancing Axl mRNA and protein expression in a dose-dependent manner. This evidence concerns the gene MZF1 and cancer.