Nevertheless, there are also relevant studies proposing that sulindac sulfide sensitizes cancer cells to trail-induced apoptosis by upregulating MZF1, inducing the expression of death receptor 5 (DR5) in tumor necrosis factor-related apoptosis inducing ligand (TRAIL), which interacts with adaptor proteins (e.g., FADD) and activates caspases to promote apoptosis in colon cancer cells [105]. This evidence concerns the gene TNFRSF10B and malignant colon neoplasm.