BRCA2 and colorectal cancer: To this end, we used three different models, consisting of pairs of BRCA2-deficient or proficient cells: (1) CAPAN1, which lacks a functional BRCA2 allele [32,33], and the respective syngenic BRCA2/CIN cell line complemented to express wild-type BRCA2 [23]; (2) the homozygous BRCA2 knockout colorectal cancer cell line DLD1 termed DLD1 BRCA2KO vs. wild-type DLD1 cells [24] and (3) BRCA2 deficient HCT116 vs. BRCA2-proficient SW620 [30].