In conclusion, we verified that LINC01537 expression is positively correlated with RIPK4/NF-κB-p65 expression, and that GC patients with high RIPK4/NF-κB-p65 have a worse prognosis, proving that LINC01537 promotes the malignant phenotype of GC cells by activating the RIPK4/NF-κB-p65 signaling pathway. Here, NFKB1 is linked to gastric cancer.