Of note, different studies have shown that the co-occurrence of MDS with LGL clones could be related to the recurrence of some mutated genes, such as NRAS [86], ASXL1, STAG2 [87], and U2AF1, while some disease-defining genes, such as SF3B1, are mutated equally in MDS/LGL and MDS alone [69]. This evidence concerns the gene SF3B1 and myelodysplastic syndrome.