Furthermore, we utilized GEPIA2021 to explore the expression of PGK1 in the different polarization sub-types of these immune cells and found that PGK1 expression was significantly higher in macrophage M2 and lower in the activated dendritic and mast cells in LUAD, suggesting that PGK1 might mediate the immune escape of lung adenocarcinoma tumor cells, as a result of the interaction between highly proliferative tumor cells and immune microenvironment cells in competing for nutrients (e.g., glucose); however, the specific molecular mechanism requires further experimental elucidation [14,56]. Here, PGK1 is linked to lung adenocarcinoma.