ZNF683 and neoplasm: Additionally, we visualized that the infiltration level of effector T cells, including CD8-GZMK-FOX, CD8-ZNF683, and CD8-GZMK, were negatively correlated with PGK1 expression in tumor cells (Figure 8B–D), which also verified our idea that a higher expression of PGK1 in tumor cells could promote the generation of an immunosuppressive microenvironment.