Westphal et al. reported the overexpression of the genes EGFR, PAK1, and MAP2K1 (mitogen-activated protein kinase kinase 1; also known as MEK1) in PC tumors as assessed by WES, RNA sequencing (RNA-Seq), and comparative genomic hybridization analyses [31]. The gene discussed is MAP2K1; the disease is pachyonychia congenita.