Interestingly, patients with higher levels of PPP2R1B and PPP2CA mRNAs have significantly worse survival (HR = 2.04 and 3.03, respectively), again highlighting the pleiotropic role of PP2A in GBM and supporting the disapproval of the classical hypothesis that PP2A is a bona fide tumor suppressor gene. This evidence concerns the gene PPP2CA and glioblastoma.