MAPK1 and cancer: However, tissue-specific microRNAs such as miR-375 and miR-383 in HPV-associated cancers and lung adenocarcinomas, respectively [66,67], and the activation of upstream signaling pathways such as EGFR-MEK-Erk [68], and Scr/Erk [69] may contribute to the upregulation of CIP2A and other PP2A inhibiting proteins.