HK2 and ovarian carcinoma: TAMs through lysophosphatidic acid (LPA) are known to induce pseudohypoxia in ovarian cancer cells through HIF1α via Gαi2, Rac1, and NOX2 axis, which results in upregulation of the glycolytic enzyme hexokinase-2 (HK2) and glucose transporter-1 (GLUT1).