The possible mechanisms of TGF-β-mediated tumor progression are numerous and may involve the following: (1) promotion of neo-angiogenesis [15], (2) increased invasion and motility through upregulation of epithelial—mesenchymal transition signaling [16,17], (3) inflammation in some tumors [18], and (4) escape from the immune surveillance [19,20]. This evidence concerns the gene TGFB1 and neoplasm.