Activation of mTORC1 activates the S6 kinase (S6K) and repressed the eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) in an AKT-dependent manner in phosphatase and Tensin homolog (PTEN)-deficient prostate cancer cells [146]. The gene discussed is RPS6KB1; the disease is Familial prostate cancer.