EGFR-NF-κB crosstalk has been reported in the following contexts: (i) EGFR activates NF-κB either directly or indirectly through various pathways in normal or cancer cells including human ER negative [ER(−)] breast cancer cells [34,35,36,37,38,39,40,41,42,43] and (ii) the IKK/NF-κB axis activates EGFR signaling in human cancer cells [44,45,46,47]. This evidence concerns the gene ESR1 and breast carcinoma.