More interestingly, an adaptive survival program is induced by EGFR inhibition, leading to rapid formation of the EGFR-tumor necrosis factor receptor-associated factor 2 (TRAF2)-receptor-interacting protein 1 (RIP1)-IKK complex to activate NF-κB in non-small cell lung cancer xenograft model [128]. The gene discussed is NFKB1; the disease is non-small cell lung carcinoma.