TNF and neoplasm: For this purpose, we investigated the systemic inflammatory profile by analyzing the levels of tumor necrosis factor-alpha (TNF-α), interleukin 4 (IL-4), interleukin 17A (Il-17A), and interleukin 12 (IL-12), as well as oxidative stress markers and tumor expression of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), transforming growth factor-beta 1 (TGF-β1), CD8, and CD4 tumor immune infiltrate.