STING1 and Anxiety: Collectively, the above data indicated that STING may contribute to CIBP via promoting microglia polarization to the M1 phenotype, which is a pro-inflammatory phenotype, STING antagonist C-176 may exert analgesic and anti-anxiety effects by inhibiting the polarization of microglia into the M1 pro-inflammatory phenotype and promoting M2 polarization in the mPFC.