For example, Cullin 1 (CUL1), V-Myb avian myeloblastosis viral oncogene homolog-like 2 (MYBL2), mutant tumor protein 53 (TP53), and hepatoma-derived growth factor (HDGF) were identified as tumor promoter genes in GB and used as targets in pre-clinical studies [8,9,10,11]. This evidence concerns the gene CUL1 and neoplasm.