GLI1 and neoplasm: For example, the overexpression of Gli1, a key protein in the Hh pathway, is considered as a symbol of Hh pathway activation and is able to activate oncogene target genes such as Cyclin-D1, Myc, Bcl-2, Ang1/2, Snai1, Nanog, and Sox2 to promote carcinogenesis and tumour development [43].