Pyrrol-2-ones belong to a class of biologically active compounds [24,25,26,27] that possess different types of pharmacological activities; among others, inhibition of plasminogen activator inhibitor-1 (PAI-1) [28], anti-inflammatory [29] or antitumoral effects [24] have been reported on ER− and ER+ BC cells. The gene discussed is SERPINE1; the disease is breast cancer.