Multivariate regression analysis identified LPO levels over the OOP (LPO > 315.39 μM) as an independent risk factor of the NASH score of ≥ 4 in NAFLD patients [OR: 4.71; 95% CI: 1.68–13.19; p = 0.003] (Table 3). This evidence concerns the gene LPO and metabolic dysfunction-associated steatohepatitis.