This study is the first study to demonstrate that metabolic syndrome significantly disturbs oxidative stress regulation, and the regulation of neurotransmitters such as ACh, monoamines, and GABA, by increasing the enzyme activities in their inactivation process such as AChE, MAO, and GABA-T, and this can lead to anxiety, sleep disturbances such as insomnia, and memory impairment. Here, ACHE is linked to insomnia measurement.