Given the fact that RIPK1 plays a critical role in modulating NF-κB activation via both cell-autonomous and non-autonomous mechanisms and that NF-κB pathways are indispensable for microglia to produce proinflammatory cytokines that generate inflammation and cause oxidative stress in neurodegenerative diseases [42,43], it is tempting to speculate that RIPK1 may be an important regulator of microglial neurotoxicity in promoting the pathological process of neurodegenerative diseases. Here, RIPK1 is linked to neurodegenerative disease.