Other than DAM, which is characterized by upregulated genes that impair lysosomal and phagocytic pathways while containing minor changes to a number of proinflammatory genes and NF-κB target genes, we recently have also identified a novel inflammatory microglia state in ALS that is regulated by RIPK1 kinase activity, named RIPK1-Regulated Inflammatory Microglia (RRIM) [63]. The gene discussed is NFKB1; the disease is amyotrophic lateral sclerosis.