Moreover, a combination of NOX2 depletion and Dex treatment did not exert a greater beneficial effect on hypoxia-induced oxidative stress and cognitive deficits than NOX2 depletion alone, indicating that the neuroprotection of Dex against neurological deficits caused by neonatal hypoxia was NOX2-dependent in the hippocampus. Here, CYBB is linked to Cognitive impairment.