This therapeutic potential of H. itama bee bread subsequently improved lipid metabolism-related genes (SREBP-1c, FAS, PPARα and CPT1α) and its regulators SIRT1 and AMPK; hence, lipid accumulation and the progression of NASH were alleviated in the liver of obese rats. The gene discussed is SIRT1; the disease is metabolic dysfunction-associated steatohepatitis.