We also focused on and demonstrated the therapeutic effects of H. itama bee bread in inhibiting Keap1, activating the Nrf2 antioxidant pathway and then restoring the dysregulation of genes associated with hepatic lipid metabolism such as SREBP-1c, FAS, PPARα and CPT1α, as well as its modulators such as SIRT1 and AMPK, being consistent with its increase in glycogen accumulation and reduction in hepatic steatosis and progression towards NASH in the liver of obese male rats. Here, SIRT1 is linked to fatty liver disease.