New blood vessel formation (angiogenesis) in the peritoneal membrane, which can be regulated by IL-8 [41], plays an indispensable role during the development of peritoneal fibrosis and, in turn, with associated peritoneal ultrafiltration failure progression that is often found in long-term PD patients [26]. The gene discussed is CXCL8; the disease is Peritoneal Fibrosis.