TNFRSF11B and Osteopenia: Apart from that, a randomized, double-blinded, placebo-controlled trial evaluated the effects of 12-week γ- and δ-tocotrienols supplementation on the levels of receptor activator of nuclear kappa-B ligand (RANKL), osteoprotegerin (OPG), bone markers bone alkaline phosphatase (BALP), and N-terminal telopeptide (NTX) as well as oxidative stress biomarkers (8-hydroxy-2′-deoxyguanosine, 8-OHdG) in postmenopausal women with osteopenia, also showing positive results.