Mancuso et al. [3] further reported that DNA double-strand breaks (DSBs) and apoptotic cell death in the non-irradiated cerebellum were caused by irradiation, with the skull shielded, in Patched-1+/− (Ptch1+/−) mice, thereby resulting in a significant increase in the medulloblastoma rate (39%) compared to the sham-treated group. Here, PTCH1 is linked to medulloblastoma.