APP and Alzheimer disease: Increased PINK1, Parkin and ubiquitinated mitochondrial proteins were found in APP transgenic mice and in pyramidal hippocampal neurons isolated from AD patients [82], but accumulation of tau protein might increase ∆ψm, preventing PINK1 and Parkin recruitment to the OMM [83] and is also able to sequester Parkin in the cytosol via interaction with the projection domain of tau [84].