Moreover, apoptosis signal-regulating kinase 1 (ASK1) has a vital role in the pathogenesis of neurodegenerative disorders, including AD [117], and Trx is bound directly to the N-terminal region of ASK1 [118] and induces dissociation of Trx from ASK1 in the oxidative stress state. Here, MAP3K5 is linked to Alzheimer disease.