In accordance, the administration of nuclear factor erythroid 2-related factor 2 (Nrf2) transcription factor activators, such as sulforaphane or oltipraz, inhibited the depressive- and anxiety-like behaviors accompanying chronic neuropathic pain in mice [21,22], and TBE-31 and MCE-1 are two possible candidates for treating the inflammation-associated depressive behaviors [23]. Here, NFE2L2 is linked to Anxiety.