HMOX1 and osteoarthritis: These outcomes were corroborated by other studies performed with H2 [54] and with other compounds such as hydrogen sulfide donors and several antioxidants, which also activated the Nrf2/HO-1 and/or NQO1 pathway for alleviating chronic inflammatory, osteoarthritis, and neuropathic pain in rodents [5,21,45,55].