In short, Grewia asiatica berry juice, heat-killed Lactobacillus helveticus strain MCC1848, alkaloids from lotus plumule, and curcumin could ameliorate depression, and the potential mechanisms included the modulation of the cholinergic system, suppression of mitochondrial apoptotic pathways, inhibition of BDNF-mediated endoplasmic reticulum stress, improvement of synaptic function, and promotion of nervous system development and signal transduction. This evidence concerns the gene BDNF and major depressive disorder.