The study of the signaling pathways regulating Glo2 expression as well as those driven by Glo2 to control specific biological responses dates back to 2006 when Xu and colleagues [30] demonstrated, for the first time, in breast cancer MCF7 cell lines, that Glo2 can be up-regulated by the p53-related genes p63 and p73 through a specific responsive element located in the intron 1 of Glo2 gene. This evidence concerns the gene HAGH and breast cancer.