In particular, in prostate cancer, it has been shown that activation of the pyruvate kinase PKM2-mediated estrogen receptor alpha (ERalpha) axis leads to Glo2 up-regulation, and that Glo2 expression via a mechanism involves the p53–p21 axis evading the apoptotic process and stimulating proliferation [31]. Here, ESR1 is linked to Familial prostate cancer.