HAGH and neoplasm: Since Glo2 and Glo1 are frequently overexpressed in cancer as a strategy to avoid accumulation of high levels of cytotoxic MGO, forming in local hypoxic malignant environment by increasing the level of glycolysis [153], and p63 and p73 [154] are overexpressed in some types of cancers [155], where they might have a tumor-promoting role [154], the authors suggested that the p63/p73–Glo2 axis might have been a novel pathway in human carcinogenesis, at least in some cases.