In this study we analyzed the expression of GPX4, GR, NQO1, and GSH, the focal node of the endogenous lipid-targeted antioxidant response, in fibroblasts of patients with AMN, the late onset and slowly progressive form of X-ALD, and in cALD, the cerebral inflammatory demyelinating form of early childhood, with the main objective to understand if they were differently modulated in the two clinical forms of the disease. Here, GPX4 is linked to adrenoleukodystrophy.