As suggested by the authors, mechanisms of the association of low 25(OH)D3 level with stroke severity may include dysregulation of the ischemia-induced inflammation, suppression of neurotrophic factor synthesis e.g., insulin-like growth factor 1(IGF-1), reduction of tissue plasminogen activator secretion, and attenuation of nitric oxide-mediated vasodilatation [144]. This evidence concerns the gene IGF1 and ischemia.