Specifically, irisin acts both on neuroplasticity and synaptic health, favoring the release of neurotrophic factors (including BDNF) [188] and on acute brain injury: indeed, in a post-stroke brain, the ischemic damage usually activates the NOD-like receptor pyrin 3 (NLRP3) inflammasome that is responsible for mediating the inflammatory response, and it was demonstrated that irisin alleviates neuronal injuries inhibiting the NLRP3 inflammatory pathway [189]. This evidence concerns the gene FNDC5 and stroke disorder.