Vitamin D reduced oxidative stress by promoting the expression of Nrf2 in neuronal cell line SK-N-SH: Since vitamin D showed protective effect from hyperglycemia-induced oxidative stress, we have hypothesized that it might be triggering the antioxidant mechanisms in the cells through either (a) promoting the expression of antioxidant proteins or (b) by inactivating the inhibitory molecules that negatively acts on antioxidant defense system. The gene discussed is NFE2L2; the disease is Hyperglycemia.