In the current study, we found that, compared with the DSS group, both PSPE and PSPc supplementation could reduce the DAI values, decrease the levels of TNF-α and IL-1β, decrease the mRNA expressions of IL-6, COX-2, and iNOS, down-regulated the levels of MDA, and increase the levels of tight junction protein, MUC-2 and goblet cells in colitis mice. The gene discussed is IL1B; the disease is colitis.