NFE2L2 and Cognitive impairment: Resveratrol pretreatment-induced intracellular Nrf2 phosphorylation, GSH and phase 2 enzymes in a 6-OHDA-injected PD rat model, thereby reducing ROS-induced DA neuronal apoptosis; promoting mitochondrial activity; restoring proteasome system function; and reducing inflammation, ER stress and behavioral/cognitive impairments [95].