265; MPO (depression severity) F = 0.769, df = 1, p = 0.385; MPO (depression severity × time) F = 3.828, df = 1, p = 0.056; covariate age: F = 2205, df = 1, p = 0.144; covariate sex: F =3.937, df = 1, p = 0.053; covariate coronary artery disease (number of affected vessels): F =2.764, df = 1, p = 0.102. This evidence concerns the gene MPO and major depressive disorder.