ANCOVA: MPO (depression) F = 4.764, df = 1, p = 0.031; MPO (time) F = 0.309, df = 1, p = 0.580; MPO (depression × time) F = 0.466, df = 1, p = 0.497; covariate age: F = 0.048, df = 1, p = 0.828; covariate sex: F =0.657, df = 1, p = 0.419; covariate coronary artery disease (number of affected vessels): F =0.034, df = 1, p = 0.854; covariate maximum creatinine kinase (CK max): F =0.206, df = 1, p = 0.651; covariate BMI: F =0.330, df = 1, p = 0.567. This evidence concerns the gene MPO and major depressive disorder.