Hypocretin input in the locus coeruleus improves fragmented sleepiness in hypocretin receptors 1 and 2 double-knockout mice, whereas dorsal raphe specific to the serotoninergic pathway can prevent cataplexy, and activation of the GABAB pathway in hypocretin-neuron-deficient mice significantly alleviates cataplexy [101]. Here, HCRTR1 is linked to Cataplexy.