PLAT and infarction: In 2011, Lansberg MG et al. [8] continued to review and analyze a total of 174 patients from the DEFUSE and echoplanar imaging thrombolytic evaluation (EPITHET) trials using the RAPID software, and observed that the patients with target mismatches (PWITmax>6s lesion volume/DWI lesion volume > 1.2, DWI or PWITmax>8s lesion ≤ 100 mL, and |PWITmax>6s lesion volume − DWI lesion volume| ≥ 10 mL) achieved a better clinical prognosis following intravenous tissue plasminogen activator (tPA) reperfusion therapy, which could slow down the increase in infarction volume.